The role of miRNAs in regulating the expression of flavonol pathway genes and its possible impact on the suppression of UV-B responses by flg22 signal cascades in Arabidopsis


 

Team: Zheng Zhou, Dirk Schenke

Supported by the Chinese Scholarship Council (CSC), 2015-2019    

 

Objectives

The modulation of miRNA levels plays an important role in reprogramming plant responses to various stresses, including nutrient deficiency, drought, cold, salinity, and mechanical stress as well as in plant–pathogen interactions. Small RNA (sRNA) directed RNA-induced silencing complex (RISC) activities regulate many biological pathways in plants. There are two potential mechanisms of sRNA–mediated gene regulation: RNA endonucleolytic cleavage at the center of sRNA–target hybrids and translation repression. The majority of targets miRNAs are transcription factors which regulate gene expression. It is of great scientific significance and practical relevance to explore the role of miRNAs in the crosstalk between UV-B and flg22 signal cascades. In the course of the project, following activities are planned:

 

  • Identification of key miRNAs, target genes and miRNA-target-interactions 

 

  • Functional characterization of miRNAs and their targeting genes

 

  • The model of function of plant miRNAs in the crosstalk between UV-B and flg22 signal cascades 

 

  • Potential use in practice